concept

AMYLOID BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

713Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	AMYLOID BETA
Key Genes/Proteins	TRKB, APP
Related Diseases	Alzheimer's Disease, Alzheimer Disease, Parkinson's Disease with Dementia

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AMYLOID_BETA["<b>AMYLOID BETA</b>"]
    AMYLOID_BETA -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AMYLOID_BETA -->|"binds"| Microglia["Microglia"]
    AMYLOID_BETA -->|"activates"| Microglial_Activation["Microglial Activation"]
    AMYLOID_BETA -->|"contributes to"| MAP1LC3B["MAP1LC3B"]
    AMYLOID_BETA -->|"contributes to"| SQSTM1["SQSTM1"]
    AMYLOID_BETA -->|"activates"| astrocytes["astrocytes"]
    AMYLOID_BETA -->|"regulates"| autophagy["autophagy"]
    AMYLOID_BETA -->|"causes"| reactive_astrocytes["reactive astrocytes"]
    AMYLOID_BETA -->|"activates"| Autophagy["Autophagy"]
    MAP1LC3B -->|"inhibits"| AMYLOID_BETA
    SQSTM1 -->|"inhibits"| AMYLOID_BETA
    Autophagy -->|"targets"| AMYLOID_BETA
    Intramural_Periarterial_Draina["Intramural Periarterial Drainage"] -->|"involved_in"| AMYLOID_BETA
    Glymphatic_Pathway["Glymphatic Pathway"] -->|"mediates"| AMYLOID_BETA
    Dam["Dam"] -->|"interacts"| AMYLOID_BETA
    SCARA1["SCARA1"] -->|"binds"| AMYLOID_BETA
    AGER["AGER"] -->|"binds"| AMYLOID_BETA
    Lysosomes["Lysosomes"] -->|"involved_in"| AMYLOID_BETA
    CD36["CD36"] -->|"binds"| AMYLOID_BETA
    FPR2["FPR2"] -->|"binds"| AMYLOID_BETA

Outgoing (277)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer Disease	involved_in	disease	0.95
Microglia	activates	cell_type	0.95
Neuroinflammation	causes	process	0.95
Parkinson's Disease with Dementia	associated_with	disease	0.95
Alzheimer'S Disease	causes	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Retinal Degeneration	causes	phenotype	0.95
Neuritic Plaques	involved_in	phenotype	0.95
Parkinson'S Disease With Dementia	involved_in	disease	0.95
Neuritic Plaques	promotes	phenotype	0.95
Alzheimer's Disease	drives	disease	0.95
ALZHEIMER'S DISEASE	associated_with	disease	0.92
MAP1LC3B	contributes_to	gene	0.90
SQSTM1	contributes_to	gene	0.90
microglia activation	promotes	process	0.90
Alzheimer's Disease	causes	disease	0.90
Microglia Activation	activates	process	0.90
Central Neuroinflammation	causes	process	0.90
Retina	expressed_in	cell_type	0.90
Oxidative Stress	causes	process	0.90
LC3B	upregulates	gene	0.90
SQSTM1	upregulates	gene	0.90
TRKB	degrades	protein	0.90
Alzheimer'S Disease	biomarker_for	disease	0.90
Optic Nerve Sheath	transports	cell_type	0.90
Senile Plaques	contributes_to	phenotype	0.90
Alzheimer Disease	causes	disease	0.90
Amyloid Plaques	mediates	phenotype	0.90
Striatum	associated_with	brain_region	0.90
Microglia	interacts_with	cell_type	0.90
Cognitive Decline	contributes_to	phenotype	0.90
neuroinflammation	promotes	process	0.88
Synaptic Structure	modulates	phenotype	0.88
Synaptic Plasticity	inhibits	process	0.88
LRP8	antagonizes	protein	0.85
Chronic Neuroinflammation	causes	process	0.85
Alzheimer's Disease Progression	associated_with	process	0.85
Neuronal Apoptosis	causes	process	0.85
Insulin Resistance	contributes_to	process	0.85
Insulin Resistance	promotes	process	0.85
Visual Impairment	causes	phenotype	0.85
Neuron	causes	cell_type	0.85
Oligodendrocyte Progenitor Cell Senescence	causes	process	0.85
Apoptosis	causes	process	0.85
Lysosomal Dysfunction	associated_with	process	0.85
Lipid Dyshomeostasis	causes	phenotype	0.85

Incoming (436)

Source	Relation	Type	Str
Donanemab	targets	drug	0.95
Anti-Amyloid Beta Therapies	targets	drug	0.95
Γ-SECRETASE	cleaves	enzyme	0.95
Alzheimer'S Disease	associated_with	disease	0.95
APP	mediates	protein	0.95
MAP1LC3B	inhibits	protein	0.90
SQSTM1	inhibits	protein	0.90
Amyloid-targeting therapy	associated_with	process	0.90
Autophagy	targets	process	0.90
Intramural Periarterial Drainage	involved_in	process	0.90
APP	product_of	protein	0.90
Hdac Inhibitors	associated_with	drug	0.90
Autophagy	degrades	process	0.90
Lyso-Chr2	promotes	protein	0.90
AQP4	associated_with	gene	0.90
Cerebrospinal Fluid	transports	cell_type	0.90
Ocular Glymphatic System	transports	process	0.90
D-520	targets	drug	0.90
Disease-Associated Microglia	interacts_with	cell_type	0.90
Glymphatic System	transports	pathway	0.90
Amyloid-Related Imaging Abnormalities	associated_with	biomarker	0.90
LL37	binds	protein	0.90
Lysosomes	involved_in	cell_type	0.85
Tirzepatide	inhibits	drug	0.85
APP	regulates	entity	0.85
Defective Insulin Signaling	upregulates	process	0.85
Hdac Inhibitors	inhibits	drug	0.85
Secretases	regulates	enzyme	0.85
ACE1	associated_with	enzyme	0.85
Disease-modifying therapy	targets	drug	0.85
Microglia	involved_in	cell_type	0.85
Blood-Brain Barrier	transports	brain_region	0.85
reactive oxygen species	contributes_to	phenotype	0.80
astrocytic autophagy	inhibits	phenotype	0.80
APOE	interacts_with	gene	0.80
alpha synuclein	interacts_with	protein	0.80
PARKIN	interacts_with	gene	0.80
Oxidative Stress	upregulates	process	0.80
Mitochondrial Dysfunction	upregulates	process	0.80
Hyperbaric Oxygen Therapy	targets	drug	0.80
Microglia	interacts_with	cell_type	0.80
Astrocytes	interacts_with	cell_type	0.80
AUTOPHAGY	clears	process	0.80
APOE	transports	protein	0.80
Microglia	transports	cell_type	0.80
IDE	degrades	protein	0.80
SQSTM1	regulates	gene	0.70
APP	encodes	gene	0.70
APP	encodes	gene	0.70
SQSTM1	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMYLOID BETA

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

NPM1 Gene

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub